Cell proliferation after ischemic infarction in gerbil brain
نویسندگان
چکیده
منابع مشابه
Cell proliferation after ischemic infarction in gerbil brain.
In order to study cell proliferation after ischemic infarction, a model of bilateral common carotid artery occlusion in the gerbil was developed. A comparison of survival rates after 15, 30, 45 and 60 min of occlusion revealed that 45 min was the maximum duration of ischemia after which most (72%) of the gerbils were alive at 1 week. The administration of pentobarbital (single dose, 30 mg/kg) p...
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Stroke is the third most common cause of mortality and the leading cause of disability in the United States. There are about 700,000 new cases each year with ischemic brain infarction accounting for almost 85% of all strokes. In this issue of CNS Spectrums, new and potential treatments for acute ischemic stroke and the cognitive changes that often result are discussed. There are approximately 3...
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The efficacy of pentobarbital in the treatment of ischemic cerebral edema was evaluated in 160 gerbils. Animals underwent carotid ligation under ether or pentobarbital (50 mg/kg) anesthesia. The pentobarbital anesthetized group received an additional dose of 30 mg/kg 4 h after ligation. Animals were evaluated for neurologic deficit at 4 and 8 h post-ligation, then sacrificed. Water content of e...
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We have previously demonstrated that transient cerebral ischemia induces marked decreases in concentrations of cytoskeletal proteins and have suggested putative involvement of calpain in the decrease of microtubule-associated protein 2 (MAP2) content. We examine the effect of nilvadipine, a new calcium channel blocker, on protein degradation in gerbil brains after 5 minutes of bilateral carotid...
متن کاملNeuropathologic changes in the gerbil brain after chronic hypoperfusion.
BACKGROUND AND PURPOSE An animal model has been developed to elucidate the pathological changes in brain cytoskeletal proteins during chronic hypoperfusion. METHODS Newly designed coiled clips were placed around both carotid arteries of Mongolian gerbils (n = 10) to cause stenosis without occlusion. Those gerbils showing impaired learning ability by the passive avoidance paradigm were killed ...
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ژورنال
عنوان ژورنال: Brain Research
سال: 1985
ISSN: 0006-8993
DOI: 10.1016/0006-8993(85)90183-0